By real world analogy, the early-contact natives of Middle America were fairly accommodating to the future conquistadors. Later, after their gold got stolen, and most of them got killed by disease, guns, and swords, they weren't so nice.
The funny thing about the in-game events is that Asriel Octavius insulted them (I even have the letters saved because it was so hilarious...ly a bad decision), Vesna Valentine stole about 2000 gold from them, Bowie Ironsides walked around crowing about being a bunch of stuff he wasn't, Joash Hamarson refused to bar Bowie Ironsides sanctuary in Summerdale and went so far as to say that they wouldn't bow to anyone (might have said something to tick off the daimons). I think that covers recent events. So, no dead natives yet, but gold was stolen by an outlander, and some of them have unleashed disease-ridden mouths spewing poorly chosen words on the Zuma. That covers 2 out of 3 things so far mentioned that would push just about any civilization to be more cynical and hostile than usual.
Of course, the aforementioned things might not have even mattered, but isn't it much better to think such a connection exists?
