Well, I have no intentions to classify the Manifest Path as anything, but I don't think it covers what I meant by "handicap".
While considering the Zuma evil and unacceptable would be a big-time handicap in the Maroccidens and Far East, threatening your very safety, in the Lurias it is not more than an oddity. We can publicly curse the Zuma at will, and nothing will happen, they won't send a Daimon army all the way here (though that /would/ be interesting... :p). Regarding being opposed to the Astroists, in theory which religion isn't? And the MP is not opposed to them to the point of considering enemies like the Daimons, or we would have seen different diplomatic relations with Morek. So, yea, so far I don't really see serious handicaps.
What I mean with handicaps were more like random superstitions that actually harm a character's goals. Focusing on a very-long-term plan on colonizing its way to the Zuma is not very harming, it is actually a goal or fuel for its own goals. And it is easily avoidable by considering the Flow Peninsula or the Divide are also not hosting civilized humanity. I meant something more like an army not daring pass through a region before a priest/druid sanctifies it for considering the grounds cursed or before the stars in a menacing position change, a character making random handicapping vows for personal reasons, a unit refusing to stay in any other place than in the front with max retreat options to show courage and such, a Lord unnecessarily hanging rebells in his region because he saw signs of heresy or messages from above indicating so. RP-rich options that do not necessarily go well with power-gaming or simply max-efficiency gaming.