I prefer the simplicity of warning message, then no takeovers. I like the concept of a ruler Abandoning a Region. I like low-density realms blocked from TOing being able to TO a higher-density realm's region into rogue status.
I'm thinking of warning message for realms below 3 nobles per region and blocked takeovers/converting-region-to-rogue takeovers for realms below 2 nobles per region.
EDIT: Upon further reflection of some realm densities on certain continents, I might be more inclined to block TOs/allow converting to rogue TOs for realms under 1.5, and raise it to 2 at a later time.